Numerous people search for a “cannabis store near me” to acquire marijuana, whether for therapeutic reasons or just for enjoyment. It’s widely understood that cannabis products can help alleviate symptoms such as anxiety, depression, discomfort, nausea, and vomiting. Have you ever pondered its influence on gastrointestinal disorders?
Table of Contents
Key Takeaways:
- Cannabinoids from the weed interact with the endocannabinoid system in the GI tract.
- weed and pain relievers can aid in managing Irritable Bowel Syndrome symptoms.
- weed serves various functions, but most individuals recognize it for its recreational and medical uses.
Gastrointestinal Disorders and weed
The dietary impact of nutraceuticals on gastrointestinal (GI) health is well-documented. Certain diets have shown potential in preventing or alleviating various GI disorders. Researchers have identified and analyzed the food components responsible for these effects.
Among the plant-based nutraceuticals that may be beneficial for GI disorders are those derived from weed. weed refers to products sourced from the weed Sativa plant, an aromatic annual flowering herb.
John M. McPartland concluded in a scientific review that the Cannabaceae family includes the genera Cannabis, Humulus, and Celtis. Within the weed genus, Sativa encompasses three varieties: Sativa, Indica, and Ruderalis. Depending on the variety, weed serves various purposes, such as fiber production, oil extraction from seeds, and primarily, recreational or medicinal use.
The Impact of weed
Receptors and ligands of the endocannabinoid system are distributed throughout different areas and systems, both within and outside the GI tract, relevant to regulating GI functions. The presence of cannabinoid receptors allows cannabinoids, including non-psychoactive phytocannabinoids, to help regulate GI functions in health and disease. The ECS plays a role in managing motility, secretion, epithelial barrier function, and viscerosensitivity.
Irritable Bowel Syndrome (IBS)
IBS has various contributing factors, affecting 10–20% of individuals in developed countries. It presents as functional gastrointestinal disturbances without identifiable organic causes.
The enhancement of the antinociceptive properties of cannabinoids in the context of inflammation highlights the importance of the ECS in visceral hypersensitivity. This discovery not only clarifies the mechanisms behind conditions like IBS and other gastrointestinal disorders but also suggests promising therapeutic possibilities for alleviating abdominal and visceral discomfort.
Cannabinoids alone may not provide substantial relief in reducing visceral hypersensitivity in IBS patients. Investigating combinations with other pain-relieving agents, like opioids, offers an intriguing alternative avenue to consider.
Inflammatory Bowel Disease (IBD)
IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), is a complex condition of the GI tract. These diseases arise from environmental, genetic, and epigenetic factors.
Cannabidiol exhibits strong anti-inflammatory properties across various models of intestinal inflammation in mice and rats, as noted in a study published in the Journal of Frontiers in Pharmacology. Both local and systemic administration of CBD demonstrated dose-dependent improvements in disease indicators:
- Reduction of structural damage
- Mitigation of inflammation-related increases in various cytokines, chemokines, and oxidative stress markers.
A study from the Inflammatory Diseases Journal indicated that the primary finding was the challenging tolerability of the botanical extract, with 90% of patients reporting treatment-related side effects compared to 48% receiving the placebo.
A trend emerged towards improved quality of life scores and a positive shift in patients’ overall impression of change, according to the per-protocol analysis. The authors speculate that the CBD-rich botanical extract may offer therapeutic benefits to those who can tolerate its effects.
Gastrointestinal Cancer
GI cancers, including colorectal cancer (CRC), are among the most frequently diagnosed conditions in the general public.
Various studies have demonstrated CBD’s antiproliferative effects in colorectal cancer models. CBD can protect DNA from oxidative stress, increase endocannabinoid levels, and inhibit the growth of colorectal cancer cells in vitro.
The confirmation of CBD’s chemopreventive properties was established through examinations of in vivo models focusing on AOM-induced colon cancer. CBD at a dosage of 1 mg/kg resulted in a significant reduction: ACF decreased by 67%, while the number of tumors and polyps decreased by 66% and 57%, respectively. Raising the concentration to 5 mg/kg was especially effective in preventing polyp formation.
THC induces apoptosis in colorectal cancer cells by activating the CB1 receptor.
Nausea and Vomiting
Positive effects of CBD occur when paired with THC, as indicated in a study published in the British Journal of Clinical Pharmacology. CBD’s anti-nausea and anti-emetic properties may be due to the indirect stimulation of somatodendritic 5-HT1A receptors situated in the dorsal raphe nucleus. This activation of autoreceptors may lead to a reduction in the release of 5-HT in specific regions of the forebrain.
Gastroesophageal Reflux Disease (GERD)
Cannabinoids impede transient LES relaxations via a CB1-dependent mechanism in both dogs and ferrets, as reported in a study from the Journal of weed and Cannabinoid Research. These findings are significant as transient LES relaxations represent the primary mechanism underlying gastroesophageal reflux disease.
weed for GI Issues
Conclusion
Numerous studies suggest that the advantages of cannabinoids extend beyond the well-known psychoactive compound THC to include non-psychoactive molecules like CBD and others, which have received relatively less attention. The weed plant interacts with the ECS to influence the GI system, triggering various functions that may assist in managing symptoms of certain GI conditions.
Frequently Asked Questions
What can you expect when buying from online weed stores?
- Accessing your weed products in Canada from an online store opens up many options featuring both classic favorites and new offerings.
- You can expect additional benefits such as special promotions, dependable payment methods, and shipping options covering most provinces.
- Essential resources, like a blog section or contact page, are available to provide customers with insights or support during their shopping experience.
- During the purchase process, you will need to verify your age by presenting identification.
- Some stores include taxes in their product prices, while others calculate it at checkout.
- Some dispensaries accept online payments like Interac E-Transfer, while others offer cash on delivery.
What is the measurement unit when buying from a weed website?
There are two primary forms of measurement: metric and imperial units. On a weed site, you will encounter measurements in grams or ounces, allowing you to find products like 3.5 grams or 1/8 ounces.
What distinguishes weed for medical use from that used recreationally?
Medical weed and recreational weed come from the same plant species, yet their differing effects and intended uses set them apart. Medical weed acts as a therapeutic aid for specific health conditions, with a higher CBD composition compared to its recreational counterpart.
Are there ready-made joints available in a weed store?
Yes. These are available as pre-rolls. weed pre-rolls, or pre-rolled joints and blunts, are convenient options for those who prefer their weed ready to use. There is a growing trend in the popularity of pre-rolled joints infused with weed concentrates.
Do weed online stores have a physical shop?
Not all online stores have physical locations, allowing you to have your purchases delivered directly to your doorstep instead of needing to pick them up from a physical store after placing an online order.
